Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 34.8 kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active) — Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Purity >90%.

SKU: BCACP-000004 Categories: ,
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Product SKUBCACP-000004
Product DescriptionRecombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 1-54aa. [Accession | Q02223].
Uniprot No.Q02223
Gene NamesTNFRSF17
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region1-54aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight34.8 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized BCMA at 2 μg/ml can bind Anti-BCMA recombinant antibody, the EC50 of human BCMA protein is 1.912-2.488 ng/ml.;Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B at 10 μg/ml can bind human BCMA, the EC50 of human BCMA protein is 221.3-298.6 ng/ml.;Human TNFSF13B protein Fc tag captured on COOH chip can bind Human BCMA protein Fc tag with an affinity constant of 39 nM as detected by LSPR Assay.;Measured by its binding ability in a functional ELISA. Immobilized human BCMA at 5 μg/ml can bind Biotinylated human TNFSF13B , the EC50 is 0.1752-0.3657 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesB cell maturation antigen; B cell maturation factor; B cell maturation protein; B-cell maturation protein; BCM; BCMA; CD269; CD269 antigen; TNFRSF17; TNR17_HUMAN; Tumor necrosis factor receptor superfamily member 17

Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Biological Context

Subcellular Location: Cell membrane (Single-pass type III membrane protein); Endomembrane system (Single-pass type III membrane protein)
Tissue Specificity: Expressed in mature B-cells, but not in T-cells or monocytes
Disease Association: [A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2]

Product Specifications

Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 1-54aa, with C-terminal hFc1-tagged tag, molecular weight 34.8 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK

Subcellular Location

Cell membrane (Single-pass type III membrane protein); Endomembrane system (Single-pass type III membrane protein)

Disease Association

[A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2]

Tissue Specificity

Expressed in mature B-cells, but not in T-cells or monocytes

Subunit

Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6

Gene: TNFRSF17  |  Organism: Homo sapiens  |  Synonyms: B-cell maturation protein
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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