Recombinant Rat Asialoglycoprotein receptor 1 (Asgr1), partial (Active), Rattus norvegicus (Rat), Mammalian cell, N-terminal 10xHis-tagged, 29.6 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Rat Asialoglycoprotein receptor 1 (Asgr1), partial (Active)

Recombinant Rat Asialoglycoprotein receptor 1 (Asgr1), partial (Active) — Transmembrane protein predominantly expressed on hepatocytes that plays a key role in endocytosis of plasma glycoproteins that lack terminal sialic acid residues. Purity >95%.

SKU: BCACP-000315 Category:
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Product SKUBCACP-000315
Product DescriptionRecombinant Rat Asialoglycoprotein receptor 1 (Asgr1) protein is expressed from Mammalian cell with N-terminal 10xHis-tagged. It contains 61-284aa. [Accession | P02706].
Uniprot No.P02706
Gene NamesAsgr1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region61-284aa
SpeciesRattus norvegicus (Rat)
Tag InfoN-terminal 10xHis-tagged
Molecular weight29.6 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Rat Pth1r at 2 μg/mL can bind Anti-PTH1R recombinant antibody . The EC50 is 0.7384-1.203 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesAsialoglycoprotein receptor 1; ASGP-R 1; ASGPR 1; Hepatic lectin 1; HL-1; rHL-1

Function

Transmembrane protein predominantly expressed on hepatocytes that plays a key role in endocytosis of plasma glycoproteins that lack terminal sialic acid residues. Specifically recognizes terminal galactose and N-acetylgalactosamine residues, facilitating the clearance of desialylated glycoproteins from circulation. Plays thereby a role in a variety of physiological processes, such as removal of desialylated platelets, elimination of activated lymphocytes and maintenance of serum glycoprotein homeostasis.

Biological Context

Subcellular Location: Membrane (Single-pass type II membrane protein)
Tissue Specificity: Expressed exclusively in hepatic parenchymal cells

Product Specifications

Recombinant Rat Asialoglycoprotein receptor 1 (Asgr1), partial (Active) is a recombinant protein from Rattus norvegicus (Rat), expressed in Mammalian cell, covering amino acids 61-284aa, with N-terminal 10xHis-tagged tag, molecular weight 29.6 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Transmembrane protein predominantly expressed on hepatocytes that plays a key role in endocytosis of plasma glycoproteins that lack terminal sialic acid residues. Specifically recognizes terminal galactose and N-acetylgalactosamine residues, facilitating the clearance of desialylated glycoproteins from circulation. Plays thereby a role in a variety of physiological processes, such as removal of desialylated platelets, elimination of activated lymphocytes and maintenance of serum glycoprotein homeostasis. Plays a role in the removal of desialylated platelets by activating a feedback loop regulating thrombopoietin (TPO) expression via the JAK2-STAT3 signaling pathway. Contributes also to recognition and elimination of activated lymphocytes by hepatocytes that can act as cytotoxic effectors (By similarity). May also play a physiological role in the regulatory network of lipid homeostasis (By similarity). Upon ligand binding, the receptor-ligand complex is internalized and trafficked to a sorting organelle, where dissociation occurs. The receptor is then recycled back to the cell surface (By similarity)

Subcellular Location

Membrane (Single-pass type II membrane protein)

Tissue Specificity

Expressed exclusively in hepatic parenchymal cells

Subunit

Interacts with LASS2

Gene: Asgr1  |  Organism: Rattus norvegicus  |  Synonyms: Hepatic lectin 1

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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