Recombinant Mouse Fibroblast growth factor 2 (Fgf2) (Active), Mus musculus (Mouse), E.coli, N-terminal 6xHis-tagged, 18.5 kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Mouse Fibroblast growth factor 2 (Fgf2) (Active)

Recombinant Mouse Fibroblast growth factor 2 (Fgf2) (Active) — Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Purity >90%.

SKU: BCACP-000020 Categories: ,
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Product SKUBCACP-000020
Product DescriptionRecombinant Mouse Fibroblast growth factor 2 (Fgf2) protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 10-154aa. [Accession | P15655].
Uniprot No.P15655
Gene NamesFgf2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region10-154aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight18.5 kDa
ActivityThe ED50 as determined by the dose-dependent stimulation of the proliferation of NIH-3T3 cells is 0.7957-1.120 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesFibroblast growth factor 2; FGF-2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2

Function

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3.

Biological Context

Subcellular Location: Secreted; Nucleus

Product Specifications

Recombinant Mouse Fibroblast growth factor 2 (Fgf2) (Active) is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 10-154aa, with N-terminal 6xHis-tagged tag, molecular weight 18.5 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of NIH-3T3 cells is 0.7957-1.120 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity)

Subcellular Location

Secreted; Nucleus

Subunit

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2 (By similarity). Interacts with FGFBP3 (PubMed:20851768). Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling (By similarity). Interacts with SNORC (via the extracellular domain) (PubMed:28323137). Interacts with glypican GPC3 (By similarity)

Gene: Fgf2  |  Organism: Mus musculus  |  Synonyms: Basic fibroblast growth factor; Heparin-binding growth factor 2

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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