Recombinant Human Procathepsin L (CTSL) (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 37.2 kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Procathepsin L (CTSL) (Active)

Recombinant Human Procathepsin L (CTSL) (Active) — Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor. Purity >90%.

SKU: BCACP-000455 Category:
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Product SKUBCACP-000455
Product DescriptionRecombinant Human Procathepsin L (CTSL) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 18-333aa. [Accession | P07711].
Uniprot No.P07711
Gene NamesCTSL
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region18-333aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight37.2 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Human MICA at 2 μg/mL can bind Anti-MICA/B recombinant antibody . The EC50 is 0.9163-1.108 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesProcathepsin L; EC:3.4.22.15; Cathepsin L1; Major excreted protein (MEP); CTSL; CTSL1

Function

Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor. Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and localize to the nucleus where they cleave the CUX1 transcription factor and modify its DNA binding properties.

Product Specifications

Recombinant Human Procathepsin L (CTSL) (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 18-333aa, with C-terminal 10xHis-tagged tag, molecular weight 37.2 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor (PubMed:15099520). Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and localize to the nucleus where they cleave the CUX1 transcription factor and modify its DNA binding properties (PubMed:15099520)

Gene: CTSL  |  Organism: Homo sapiens

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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