Recombinant Human Interleukin-21 (IL21) (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 44.4 kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Interleukin-21 (IL21) (Active)

Recombinant Human Interleukin-21 (IL21) (Active) — Cytokine with immunoregulatory activity. Purity >90%.

SKU: BCACP-000635 Categories: ,
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Product SKUBCACP-000635
Product DescriptionRecombinant Human Interleukin-21 (IL21) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 23-155aa. [Accession | Q9HBE4].
Uniprot No.Q9HBE4
Gene NamesIL21
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region23-155aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight44.4 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis LGR5 at 2 μg/mL can bind anti-LGR5 recombinant antibody.The EC50 is 15.10-19.23 ng/mL.;LGR5 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Macaca fascicularis LGR5 with an affinity constant of 0.362 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInterleukin-21; IL-21; Za11

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells.

Product Specifications

Recombinant Human Interleukin-21 (IL21) (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 23-155aa, with C-terminal hFc1-tagged tag, molecular weight 44.4 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed:11081504, PubMed:15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity)

Gene: IL21  |  Organism: Homo sapiens

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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