Recombinant Human interleukin-16 protein (IL16), partial (Active), Homo sapiens (Human), E.Coli, Tag-Free, 13.4 kDa, purity >>95% as determined by SDS-PAGE.
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Recombinant Human interleukin-16 protein (IL16), partial (Active)

Recombinant Human interleukin-16 protein (IL16), partial (Active) — Isoform 3 is involved in cell cycle progression in T-cells. Purity >95%.

SKU: BCACP-000668 Categories: ,
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Product SKUBCACP-000668
Product DescriptionRecombinant Human interleukin-16 protein (IL16) protein is expressed from E.Coli with Tag-Free. It contains 1203-1332aa. [Accession | Q14005].
Uniprot No.Q14005
Gene NamesIL16
Purity>95% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region1203-1332aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight13.4 kDa
ActivityFully biologically active when compared to standard. The ED50 as determined by inducing IL-8 secretion of human HepG2 cells is less than 1.0 μg/ml, corresponding to a specific activity of >1000 IU/mg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesHGNC:5980; HsT19289; IL-16; IL16; IL16_HUMAN; Interleukin 16 precursor; Interleukin-16; LCF; Lymphocyte chemoattractant factor; Neuronal interleukin 16; NIL16; prIL 16; PrIL16 ; Prointerleukin 16

Function

Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Biological Context

Subcellular Location: Cytoplasm; Nucleus
Tissue Specificity: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation

Product Specifications

Recombinant Human interleukin-16 protein (IL16), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in E.Coli, covering amino acids 1203-1332aa, with Tag-Free tag, molecular weight 13.4 kDa, purity >95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells

Subcellular Location

Cytoplasm; Nucleus

Tissue Specificity

Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation

Subunit

(Microbial infection) Isoform 3 interacts with HTLV-1 tax

Gene: IL16  |  Organism: Homo sapiens
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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