Recombinant Mouse C-C motif chemokine 7 protein (Ccl7), Mus musculus (Mouse), E.Coli, Tag-Free, 8.5 kDa, purity >>95% as determined by SDS-PAGE.
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Recombinant Mouse C-C motif chemokine 7 protein (Ccl7)

Recombinant Mouse C-C motif chemokine 7 protein (Ccl7) — Chemotactic factor that plays an important role in immune regulation. Purity >95%.

SKU: BCACP-000800 Categories: ,
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Product SKUBCACP-000800
Product DescriptionRecombinant Mouse C-C motif chemokine 7 protein (Ccl7) protein is expressed from E.Coli with Tag-Free. It contains 24-97aa. [Accession | Q03366].
Uniprot No.Q03366
Gene NamesCcl7
Purity>95% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region24-97aa
SpeciesMus musculus (Mouse)
Tag InfoTag-Free
Molecular weight8.5 kDa
ActivityFully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using purified eosinophils is in a concentration range of 100-1000 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCcl7; Fic; Mcp3; Scya7C-C motif chemokine 7; Intercrine/chemokine MARC; Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; Protein FIC; Small-inducible cytokine A7

Function

Chemotactic factor that plays an important role in immune regulation. Attracts monocytes, eosinophils, basophils, and T-cells to sites of inflammation or infection. Upon binding to various chemokine receptors including CCR1, CCR2, CCR3, and CCR5, facilitates immune cell migration by guiding them to infected tissues.

Biological Context

Subcellular Location: Secreted

Product Specifications

Recombinant Mouse C-C motif chemokine 7 protein (Ccl7) is a recombinant protein from Mus musculus (Mouse), expressed in E.Coli, covering amino acids 24-97aa, with Tag-Free tag, molecular weight 8.5 kDa, purity >95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Chemotactic factor that plays an important role in immune regulation. Attracts monocytes, eosinophils, basophils, and T-cells to sites of inflammation or infection. Upon binding to various chemokine receptors including CCR1, CCR2, CCR3, and CCR5, facilitates immune cell migration by guiding them to infected tissues (PubMed:39805173). Interacts with CCR2 to facilitate the release of monocytes from the bone marrow into the bloodstream, maintaining monocyte homeostasis. In turn, monocytes recruited to inflamed or injured tissues can differentiate into macrophages or dendritic cells, which are essential for immune defense and tissue repair (PubMed:17364026). Through CCR1, contributes to macrophage polarization via NF-kappa-B activation which leads to the release of inflammatory factors (PubMed:39805173). In the trigeminal ganglion neurons, activates ERK via CCR2 and CCR3 to enhance neuronal excitability, which contributes to the maintenance of trigeminal neuropathic pain (PubMed:36998150). Additionally, modulates the early immune response in the skin, preventing pathogen dissemination while maintaining cutaneous immune control (PubMed:30671055)

Subcellular Location

Secreted

Subunit

Monomer. Interacts with TNFAIP6 (via Link domain)

Gene: Ccl7  |  Organism: Mus musculus  |  Synonyms: Intercrine/chemokine MARC; Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; Protein FIC; Small-inducible cytokine A7
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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