Recombinant Human Fms-related Tyrosine Kinase 3 Ligand (FLT3LG), partial (Active) (GMP), Homo sapiens (Human), E.Coli, Tag-Free, 17.6 kDa, purity >> 98 % by SDS-PAGE and HPLC analyses.
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Recombinant Human Fms-related Tyrosine Kinase 3 Ligand (FLT3LG), partial (Active) (GMP)

Recombinant Human Fms-related Tyrosine Kinase 3 Ligand (FLT3LG), partial (Active) (GMP) — Stimulates the proliferation of early hematopoietic cells by activating FLT3. Purity > 98 % by SDS-PAGE and HPLC analyses..

SKU: BCACP-001112 Categories: , ,
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Product SKUBCACP-001112
Product DescriptionRecombinant Human Fms-related Tyrosine Kinase 3 Ligand (FLT3LG), (GMP) protein is expressed from E.Coli with Tag-Free. It contains 27-181aa. [Accession | P49771].
Uniprot No.P49771
Gene NamesFLT3LG
Purity> 98 % by SDS-PAGE and HPLC analyses.
Expression SystemE.Coli
Expression Region27-181aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight17.6 kDa
ActivityMeasured in a cell proliferation assay using NIH3T3 mouse embryonic fibroblast cells. The ED50 for this effect is ≤2.0 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesFL; Flt 3 ligand; Flt 3L; Flt3 L; FLT3 LG; Flt3 ligand; Flt3L; FLT3L_HUMAN; Flt3lg; Fms related tyrosine kinase 3 ligand; Fms-related tyrosine kinase 3 ligand; SL cytokine

Function

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Required for the development of B cells, and dendritic cells (DCs).

Biological Context

Subcellular Location: Secreted
Disease Association: Immunodeficiency 125 (IMD125) : An autosomal recessive immunologic disorder characterized by failure to thrive and chronic diarrhea in infancy, and recurrent bacterial, viral, and fungal infections. Patients have severe human papilloma virus (HPV) infections with disseminated common warts, and the bone marrow is hypoplastic with low levels of CD34+ hematopoietic stem cells. Counts of B cells, monocytes, and dendritic cells are low in patients blood. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Fms-related Tyrosine Kinase 3 Ligand (FLT3LG), partial (Active) (GMP) is a recombinant protein from Homo sapiens (Human), expressed in E.Coli, covering amino acids 27-181aa, with Tag-Free tag, molecular weight 17.6 kDa, purity > 98 % by SDS-PAGE and HPLC analyses.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Required for the development of B cells, and dendritic cells (DCs)

Subcellular Location

Secreted

Disease Association

Immunodeficiency 125 (IMD125) : An autosomal recessive immunologic disorder characterized by failure to thrive and chronic diarrhea in infancy, and recurrent bacterial, viral, and fungal infections. Patients have severe human papilloma virus (HPV) infections with disseminated common warts, and the bone marrow is hypoplastic with low levels of CD34+ hematopoietic stem cells. Counts of B cells, monocytes, and dendritic cells are low in patients blood. [The disease may be caused by variants affecting the gene represented in this entry]

Subunit

Homodimer (isoform 2)

Gene: FLT3LG  |  Organism: Homo sapiens  |  Synonyms: SL cytokine
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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