Recombinant Human Serotransferrin (TF) (HOLO) (Active), Homo sapiens (Human), Mammalian cell, Tag free, 75.2 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Serotransferrin (TF) (HOLO) (Active)

Recombinant Human Serotransferrin (TF) (HOLO) (Active) — (Microbial infection) Serves as an iron source for parasite T. Purity >95%.

SKU: BCACP-001163 Category:
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Product SKUBCACP-001163
Product DescriptionRecombinant Human Serotransferrin (TF) (HOLO) protein is expressed from Mammalian cell with Tag free. It contains 20-698aa. [Accession | P02787].
Uniprot No.P02787
Gene NamesTransferrin
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region20-698aa
SpeciesHomo sapiens (Human)
Tag InfoTag free
Molecular weight75.2 kDa
ActivityMeasured by the ability of the immobilized protein to support the adhesion of NIH3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 2-10 μg/mL.Optimal concentration depends on cell type as well as the application or research objectives.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesSerotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF

Function

(Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed by the liver and secreted in plasma
Disease Association: Atransferrinemia (ATRAF) : A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Serotransferrin (TF) (HOLO) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 20-698aa, with Tag free tag, molecular weight 75.2 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

(Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use

Subcellular Location

Secreted

Disease Association

Atransferrinemia (ATRAF) : A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed by the liver and secreted in plasma

Subunit

(Microbial infection) Binds to Neisseria transferrin-binding protein B (tbpb or tbp2)

Gene: TF  |  Organism: Homo sapiens  |  Synonyms: Beta-1 metal-binding globulin; Siderophilin

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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