Recombinant Human Neuropeptide Y receptor type 2 (NPY2R) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 48.8kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Neuropeptide Y receptor type 2 (NPY2R) Protein

Recombinant Human Neuropeptide Y receptor type 2 (NPY2R) Protein — Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Purity >85%.

SKU: BCRECP-00162TM Category:
Online Inquiry →

Product Specifications

Uniprot No.P49146
Gene NamesNPY2R
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-381aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight48.8kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Can also bind with lower affinity pancreatic polypeptide (PP/PPY) and [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra

Product Specifications

Recombinant Human Neuropeptide Y receptor type 2 (NPY2R) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-381aa, with N-terminal 10xHis-tagged tag, molecular weight 48.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Receptor for neuropeptide Y (NPY) and peptide YY (PYY) (PubMed:7592910, PubMed:7559383, PubMed:35507650, PubMed:36525977, PubMed:38882210). Can also bind with lower affinity pancreatic polypeptide (PP/PPY) and [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:7592910, PubMed:7559383, PubMed:35507650, PubMed:38882210). Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels (PubMed:7559383, PubMed:7592910). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). As receptor for peptide PYY(3-36) in the arcuate nucleus of the hypothalamus, it is involved in the down-regulation of appetite and food intake (By similarity)

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Tissue Specificity

High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra

Subunit

Interacts with GNAI1; the interaction stabilizes the receptor in the high affinity state for NPY (PubMed:35507650, PubMed:36525977). Upon activation by NPY or PYY, interacts with ARRB2 (PubMed:36525977)

Gene: NPY2R  |  Organism: Homo sapiens  |  Synonyms: NPY-Y2 receptor
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

Shopping Cart
Scroll to Top