Recombinant Influenza A virus Matrix protein 2 (M) Protein, Influenza A virus (strain A/Chile/1/1983 H1N1), in vitro E.coli expression system, C-terminal 6xHis-tagged, 12.1kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Influenza A virus Matrix protein 2 (M) Protein

Recombinant Influenza A virus Matrix protein 2 (M) Protein — Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. Purity >95%.

SKU: BCRECP-00021TM Categories: , ,
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Product Specifications

Uniprot No.A4GCH6
Gene NamesM
PurityGreater than 95% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-97aa
SpeciesInfluenza A virus (strain A/Chile/1/1983 H1N1)
Tag InfoC-terminal 6xHis-tagged
Molecular weight12.1kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity.

Biological Context

Subcellular Location: Virion membrane; Host apical cell membrane (Single-pass type III membrane protein)

Product Specifications

Recombinant Influenza A virus Matrix protein 2 (M) Protein is a recombinant protein from Influenza A virus (strain A/Chile/1/1983 H1N1), expressed in in vitro E.coli expression system, covering amino acids 1-97aa, with C-terminal 6xHis-tagged tag, molecular weight 12.1kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not Test

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation

Subcellular Location

Virion membrane; Host apical cell membrane (Single-pass type III membrane protein)

Subunit

Homotetramer; composed of two disulfide-linked dimers held together by non-covalent interactions. May interact with matrix protein 1

Gene: M  |  Organism: Influenza A virus (strain A/Chile/1/1983 H1N1)  |  Synonyms: Proton channel protein M2

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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