Function
High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules. May have a residual high-affinity, low-capacity glucose and fructose transporter activity. Transports urate at rates 45- to 60-fold faster than glucose.
Biological Context
Subcellular Location: Cell membrane; Apical cell membrane (Multi-pass membrane protein); Basolateral cell membrane (Multi-pass membrane protein)
Tissue Specificity: Only detected in the apical membranes of polarized renal tubular cells and placenta. Detected in kidney membrane (at protein level)
Disease Association: Hypouricemia renal 2 (RHUC2) : A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-540aa, with N-terminal 10xHis-tagged tag, molecular weight 60.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
