Recombinant Human Tumor Necrosis Factor Receptor II/TNFRSF1B/CD120b Protein, HEK293 Cells, C-6His, 19.0 kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Tumor Necrosis Factor Receptor II/TNFRSF1B/CD120b Protein

Recombinant Human Tumor Necrosis Factor Receptor II/TNFRSF1B/CD120b Protein — Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. Purity >90%.

SKU: BCRETP-000048 Categories: , ,
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Product Specifications

Product SkuBCRETP-000048
Product DescriptionRecombinant Human Tumor Necrosis Factor Receptor II/TNFRSF1B/CD120b Protein is expressed from HEK293 with His tag at the C-Terminus. It contains 288-461aa. [Accession | P20333].
Uniprot No.P20333
SynonymsTumor necrosis factor receptor superfamily member 1B;Tumor necrosis factor receptor 2;TNF-R2;Tumor necrosis factor receptor type II;TNF-RII;TNFR-II;p75;p80 TNF-alpha receptor
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemHEK293 Cells
Expression Region288-461aa
Tag InfoC-6His
Molecular weight19.0 kDa
EndotoxinLess than 1.0 EU/μg as determined by LAL method.

Function

Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF.

Product Specifications

Recombinant Human Tumor Necrosis Factor Receptor II/TNFRSF1B/CD120b Protein is a recombinant protein, expressed in HEK293 Cells, covering amino acids 288-461aa, with C-6His tag, molecular weight 19.0 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity

Gene: TNFRSF1B  |  Organism: Homo sapiens

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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