Recombinant Human Cathepsin D (CTSD), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 40.8kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Cathepsin D (CTSD), partial

Recombinant Human Cathepsin D (CTSD), partial — Acid protease active in intracellular protein breakdown. Purity >90%.

SKU: BCRECP-000454 Category:
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Product Specifications

Product SkuBCRECP-000454
Product DescriptionRecombinant Human Cathepsin D (CTSD) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 67-403aa. [Accession | P07339].
Uniprot No.P07339
Gene NamesCTSD
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region67-403aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight40.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

Biological Context

Subcellular Location: Lysosome; Melanosome; Secreted, extracellular space
Tissue Specificity: Expressed in the aorta extracellular space (at protein level). Expressed in liver (at protein level)
Disease Association: Ceroid lipofuscinosis, neuronal, 10 (CLN10) : A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Cathepsin D (CTSD), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 67-403aa, with N-terminal 6xHis-tagged tag, molecular weight 40.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease

Subcellular Location

Lysosome; Melanosome; Secreted, extracellular space

Disease Association

Ceroid lipofuscinosis, neuronal, 10 (CLN10) : A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530)

Subunit

Consists of a light chain and a heavy chain (PubMed:1426530, PubMed:8393577). Interacts with ADAM30; this leads to activation of CTSD (PubMed:27333034). Interacts with GRN; stabilizes CTSD; increases its proteolytic activity (By similarity)

Gene: CTSD  |  Organism: Homo sapiens
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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