Recombinant Human F-box only protein 3 (FBXO3), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 56.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human F-box only protein 3 (FBXO3)

Recombinant Human F-box only protein 3 (FBXO3) — (Microbial infection) Associates with the Rift valley fever virus NSs to form a remodeled E3 ligase that triggers efficient proteasomal degradation of targeted proteins. Purity >90%.

SKU: BCRECP-000638 Category:
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Product Specifications

Product SkuBCRECP-000638
Product DescriptionRecombinant Human F-box only protein 3 (FBXO3) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 1-471aa. [Accession | Q9UK99].
Uniprot No.Q9UK99
Gene NamesFBXO3
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-471aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight56.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

(Microbial infection) Associates with the Rift valley fever virus NSs to form a remodeled E3 ligase that triggers efficient proteasomal degradation of targeted proteins. The filamentous E3 ligase targets the TFIIH complex leading to robust inhibition of antiviral immunity and enhances viral pathogenesis.

Biological Context

Subcellular Location: Nucleus
Pathway: Protein modification; protein ubiquitination

Product Specifications

Recombinant Human F-box only protein 3 (FBXO3) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-471aa, with N-terminal 6xHis-tagged tag, molecular weight 56.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

(Microbial infection) Associates with the Rift valley fever virus NSs to form a remodeled E3 ligase that triggers efficient proteasomal degradation of targeted proteins. The filamentous E3 ligase targets the TFIIH complex leading to robust inhibition of antiviral immunity and enhances viral pathogenesis

Subcellular Location

Nucleus

Subunit

(Microbial infection) Interacts (via ApaG domain) with Rift valley fever virus NSs helical filament; this interaction forms a filamentous E3 which mediates degradation of TFIIH complex through interaction with GT2H1

Pathway

Protein modification; protein ubiquitination

Gene: FBXO3  |  Organism: Homo sapiens
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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