Recombinant Human Glycine receptor subunit alpha-1 (GLRA1), partial, Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 33.1 kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Glycine receptor subunit alpha-1 (GLRA1), partial

Recombinant Human Glycine receptor subunit alpha-1 (GLRA1), partial — Subunit of heteromeric glycine-gated chloride channels. Purity >90%.

SKU: BCRECP-000760 Category:
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Product Specifications

Product SkuBCRECP-000760
Product DescriptionRecombinant Human Glycine receptor subunit alpha-1 (GLRA1) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 29-250aa. [Accession | P23415].
Uniprot No.P23415
Gene NamesGLRA1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region29-250aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight33.1 kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Subunit of heteromeric glycine-gated chloride channels. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents.

Biological Context

Subcellular Location: Postsynaptic cell membrane (Multi-pass membrane protein); Synapse; Perikaryon; Cell projection, dendrite; Cell membrane (Multi-pass membrane protein)
Disease Association: Hyperekplexia 1 (HKPX1) : A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Glycine receptor subunit alpha-1 (GLRA1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 29-250aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 33.1 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Subunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity)

Subcellular Location

Postsynaptic cell membrane (Multi-pass membrane protein); Synapse; Perikaryon; Cell projection, dendrite; Cell membrane (Multi-pass membrane protein)

Disease Association

Hyperekplexia 1 (HKPX1) : A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Interacts with GLRB to form heteropentameric channels; this is probably the predominant form in vivo (PubMed:22715885, PubMed:22973015, PubMed:25445488, PubMed:35526563, PubMed:37821459). Heteropentamer composed of four GLRA1 subunits and one GLRB subunit (PubMed:37821459). Heteropentamer composed of two GLRA1 and three GLRB (PubMed:22715885). Heteropentamer composed of three GLRA1 and two GLRB (PubMed:22973015). Homopentamer (in vitro) (PubMed:22715885, PubMed:22973015, PubMed:23994010, PubMed:25730860). Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (PubMed:14551753, PubMed:22715885, PubMed:22973015, PubMed:23994010, PubMed:25445488, PubMed:25730860)

Gene: GLRA1  |  Organism: Homo sapiens  |  Synonyms: Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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