Recombinant Human Heart- and neural crest derivatives-expressed protein 2 (HAND2), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 47.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Heart- and neural crest derivatives-expressed protein 2 (HAND2)

Recombinant Human Heart- and neural crest derivatives-expressed protein 2 (HAND2) — Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Purity >90%.

SKU: BCRECP-000803 Category:
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Product Specifications

Product SkuBCRECP-000803
Product DescriptionRecombinant Human Heart- and neural crest derivatives-expressed protein 2 (HAND2) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-180aa. [Accession | P61296].
Uniprot No.P61296
Gene NamesHAND2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-180aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight47.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud.

Biological Context

Subcellular Location: Nucleus
Tissue Specificity: Heart

Product Specifications

Recombinant Human Heart- and neural crest derivatives-expressed protein 2 (HAND2) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-180aa, with N-terminal GST-tagged tag, molecular weight 47.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity)

Subcellular Location

Nucleus

Tissue Specificity

Heart

Subunit

Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND1 and HEY1, HEY2 and HEYL (hairy-related transcription factors) (By similarity)

Gene: HAND2  |  Organism: Homo sapiens  |  Synonyms: Class A basic helix-loop-helix protein 26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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