Recombinant Human Interferon alpha-inducible protein 6 (IFI6), Homo sapiens (Human), E.coli, N-terminal 6xHis-B2M-tagged, 24.4kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Interferon alpha-inducible protein 6 (IFI6)

Recombinant Human Interferon alpha-inducible protein 6 (IFI6) — Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses. Purity >90%.

SKU: BCRECP-000888 Categories: ,
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Product Specifications

Product SkuBCRECP-000888
Product DescriptionRecombinant Human Interferon alpha-inducible protein 6 (IFI6) Protein is expressed from E.coli with N-terminal 6xHis-B2M-tagged. It contains 24-130aa. [Accession | P09912].
Uniprot No.P09912
Gene NamesIFI6
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region24-130aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-B2M-tagged
Molecular weight24.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses. Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells.

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Multi-pass membrane protein); Mitochondrion inner membrane (Multi-pass membrane protein)

Product Specifications

Recombinant Human Interferon alpha-inducible protein 6 (IFI6) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 24-130aa, with N-terminal 6xHis-B2M-tagged tag, molecular weight 24.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses (PubMed:31142663). Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication (PubMed:30224801). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells (PubMed:25757571). Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression (PubMed:33868257). Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746). Modulates innate immune response mediated by RIGI by preventing its activation (PubMed:36793726)

Subcellular Location

Endoplasmic reticulum membrane (Multi-pass membrane protein); Mitochondrion inner membrane (Multi-pass membrane protein)

Subunit

Interacts with CIB1; the interaction is direct. Interacts with the chaperone BIP/HSPA5 (PubMed:30224801). Interacts with RIGI (PubMed:36793726)

Gene: IFI6  |  Organism: Homo sapiens  |  Synonyms: Interferon-induced protein 6-16
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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