Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial, Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 42.6kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial

Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial — Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Purity >90%.

SKU: BCRECP-001555 Categories: , ,
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Product Specifications

Product SkuBCRECP-001555
Product DescriptionRecombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 30-391aa. [Accession | Q01973].
Uniprot No.Q01973
Gene NamesROR1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region30-391aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight42.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activates downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In the inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Cell projection, axon
Tissue Specificity: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm
Disease Association: Deafness, autosomal recessive, 108 (DFNB108) : A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 30-391aa, with N-terminal 6xHis-tagged tag, molecular weight 42.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activates downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In the inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068)

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Cell projection, axon

Disease Association

Deafness, autosomal recessive, 108 (DFNB108) : A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm

Subunit

Interacts with ERBB2 and IGFBP5

Gene: ROR1  |  Organism: Homo sapiens  |  Synonyms: Neurotrophic tyrosine kinase, receptor-related 1
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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