Function
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
Biological Context
Subcellular Location: Secreted, extracellular space, surface film
Disease Association: Pulmonary surfactant metabolism dysfunction 2 (SMDP2) : A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Pulmonary surfactant-associated protein C (SFTPC) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 24-58aa, with N-terminal GST-tagged tag, molecular weight 30.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
