Recombinant Mouse Paired immunoglobulin-like receptor B (Pirb), partial, Mus musculus (Mouse), Mammalian cell, C-terminal 6xHis-tagged, 70.8kDa, purity >90% as determined by SDS-PAGE.

Recombinant Mouse Paired immunoglobulin-like receptor B (Pirb), partial

Recombinant Mouse Paired immunoglobulin-like receptor B (Pirb), partial — May act as receptor for class I MHC antigens. Purity >90%.

SKU: BCRECP-004081 Category:
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Product Specifications

Product SkuBCRECP-004081
Product DescriptionRecombinant Mouse Paired immunoglobulin-like receptor B (Pirb) Protein is expressed from Mammalian cell with C-terminal 6xHis-tagged. It contains 25-642aa. [Accession | P97484].
Uniprot No.P97484
Gene NamesPirb
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region25-642aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 6xHis-tagged
Molecular weight70.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

May act as receptor for class I MHC antigens. Becomes activated upon coligation of PIRB and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Detected in macrophages, splenocytes and B lymphocytes (at protein level). Detected in macrophages, mast cells, splenocytes, peritoneal cells and natural killer cells

Product Specifications

Recombinant Mouse Paired immunoglobulin-like receptor B (Pirb), partial is a recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell, covering amino acids 25-642aa, with C-terminal 6xHis-tagged tag, molecular weight 70.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

May act as receptor for class I MHC antigens. Becomes activated upon coligation of PIRB and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM)

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Tissue Specificity

Detected in macrophages, splenocytes and B lymphocytes (at protein level). Detected in macrophages, mast cells, splenocytes, peritoneal cells and natural killer cells

Subunit

Part of a complex consisting of SKAP2, FYB1 and PIRB (PubMed:11207596). Interacts with PTPN6/SHP-1 and PTPN11/SHP-2, when phosphorylated by LYN at Tyr-794 and Tyr-824

Gene: Pirb  |  Organism: Mus musculus  |  Synonyms: Cell-surface glycoprotein p91; Leukocyte immunoglobulin-like receptor subfamily B member 3
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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