Recombinant Mouse Collagen alpha-3 (IV) chain (Col4a3), partial

Function

Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms

Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane

Tissue Specificity

Highly expressed in kidney and lung. Detected at lower levels in heart, muscle and skin

Subunit

There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. The alpha 3(IV) chain forms a triple helical protomer with alpha 4(IV) and alpha 5(IV); this triple helical structure dimerizes through NC1-NC1 domain interactions such that the alpha 3(IV), alpha 4(IV) and alpha 5(IV) chains of one protomer connect with the alpha 5(IV), alpha 4(IV) and alpha 3(IV) chains of the opposite promoter, respectively (PubMed:14633121). Interacts with ITGB3 (By similarity). Associates with LAMB2 at the neuromuscular junction and in GBM (PubMed:7962065)

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