Recombinant ADC Target Proteins for Antibody-Drug Conjugate Research
BioCrest Sci supplies recombinant target proteins for antibody-drug conjugate (ADC) discovery and development. The portfolio includes established and emerging tumor-associated antigens in soluble extracellular-domain, active, biotinylated, Fc-tagged, and membrane-mimetic formats for antibody screening, binding analysis, assay development, and target-validation research.
Featured ADC Targets
HER2 / ERBB2
HER2 is an established ADC target in HER2-positive and HER2-low tumor research. Recombinant ERBB2 extracellular-domain proteins support antibody binding, SPR/BLI, ELISA, and analytical assay development.
TROP2 / TACSTD2
TROP2 is a cell-surface glycoprotein investigated across multiple epithelial cancers. Active and biotinylated TACSTD2 formats can support antibody screening, kinetic analysis, and oriented immobilization.
- Recombinant Human TROP2 / TACSTD2 Protein, Active
- Biotinylated Human TROP2 / TACSTD2 Protein, Active
Claudin 18.2 / CLDN18.2
Claudin 18.2 is a multi-pass membrane target studied in gastric, gastroesophageal, and pancreatic cancer research. Soluble domains and VLP- or detergent-based formats enable different screening and binding strategies.
GPC3
Glypican-3 is a cell-surface proteoglycan studied in hepatocellular carcinoma and other solid-tumor programs. Recombinant GPC3 proteins support antibody selection, binding assays, and preclinical research.
Nectin-4 / NECTIN4
Nectin-4 is a cell-adhesion molecule and clinically validated ADC target investigated in urothelial and other epithelial cancer research.
Applications in ADC Research
- Antibody discovery, screening, and clone ranking
- SPR and BLI affinity and kinetic measurements
- ELISA, bridging, and competitive binding assays
- Target-expression and specificity studies
- Analytical method and potency-assay development
How to Choose an ADC Target Protein
Choose the species, extracellular sequence, expression system, tag orientation, biotinylation method, and membrane context according to the assay. Soluble extracellular domains are convenient for ELISA and kinetic analysis, whereas VLP or detergent formats may better preserve epitopes from multi-pass membrane targets. Product activity and validation are product-specific, so review each datasheet before use.
Catalog Products and Custom Production
Use catalog proteins when an existing sequence and format meet the assay requirements. If a different construct, species, tag, expression system, or membrane presentation is needed, explore Custom Protein Expression Services and Membrane Protein Production Services.
Frequently Asked Questions
What does ADC mean on this page?
ADC means antibody-drug conjugate. This page is intentionally separated from products whose gene or protein abbreviation is also “adc,” such as acetoacetate decarboxylase.
Which target proteins are available in membrane-mimetic formats?
Selected targets, including Claudin 18.2, are available in VLP or detergent-based formats. Availability varies by target and construct.
Are these proteins intended for clinical use?
No. Unless an individual product page explicitly states otherwise, catalog proteins are for research use only.