Mouse anti-Human sapiens (Human) CLDN7 Monoclonal Antibody

Mouse anti-Human sapiens (Human) CLDN7 Monoclonal Antibody

Mouse anti-Human sapiens (Human) CLDN7 Monoclonal Antibody — recombinant protein.

SKU: BCREC-000914MA Category:
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Product Specifications

Uniprot No.O95471
Target NamesCLDN7
Species ReactivityMouse
ImmunogenSynthesized peptide derived from human Claudin 7
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeIgG2a, Kappa
ClonalityMonoclonal
ApplicationsELISA, IHC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Plays a major role in tight junction-specific obliteration of the intercellular space.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Basolateral cell membrane; Cell junction, tight junction
Tissue Specificity: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions

Product Specifications

Mouse anti-Human sapiens (Human) CLDN7 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

Applications: ELISA, IHC

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Plays a major role in tight junction-specific obliteration of the intercellular space

Subcellular Location

Cell membrane (Multi-pass membrane protein); Basolateral cell membrane; Cell junction, tight junction

Tissue Specificity

Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions

Subunit

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM (PubMed:16054130). Does not interact with CD81 (PubMed:20375010)

Gene: CLDN7  |  Organism: Homo sapiens

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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