Mouse anti-Human sapiens (Human) PDCL3 Monoclonal Antibody
Mouse anti-Human sapiens (Human) PDCL3 Monoclonal Antibody - Image 2

Mouse anti-Human sapiens (Human) PDCL3 Monoclonal Antibody

Mouse anti-Human sapiens (Human) PDCL3 Monoclonal Antibody — Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation.

SKU: BCREC-000253MA Category:
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Product Specifications

Uniprot No.Q9H2J4
Target NamesPDCL3
Species ReactivityMouse
ImmunogenRecombinant Human PDCL3 protein
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeMouse IgG2a
ClonalityMonoclonal
ApplicationsELISA, WB, FC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes.

Biological Context

Subcellular Location: Cytoplasm; Cytoplasm, perinuclear region; Endoplasmic reticulum
Tissue Specificity: Expressed in endothelial cells (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon

Product Specifications

Mouse anti-Human sapiens (Human) PDCL3 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

Applications: ELISA, WB, FC

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430)

Subcellular Location

Cytoplasm; Cytoplasm, perinuclear region; Endoplasmic reticulum

Tissue Specificity

Expressed in endothelial cells (at protein level) (PubMed:26059764). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon (PubMed:15371430)

Subunit

Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain) (PubMed:23792958, PubMed:26059764). Forms ternary complexes with the chaperonin CCT complex and actin substrate, leading to inhibition of actin folding (PubMed:17429077). Interacts with XIAP (via BIR 3 and RING domain) (PubMed:19012568). Interacts with HSP90AA1 and HSP90AB1 (By similarity)

Gene: PDCL3  |  Organism: Homo sapiens  |  Synonyms: HTPHLP; PhPL3; Viral IAP-associated factor 1
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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