Recombinant Bovine Transforming growth factor beta-2 proprotein (TGFB2), partial, Bos taurus (Bovine), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 20.2kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Bovine Transforming growth factor beta-2 proprotein (TGFB2), partial

Recombinant Bovine Transforming growth factor beta-2 proprotein (TGFB2), partial — Multifunctional protein that regulates various processes such as angiogenesis and heart development. Purity >90%.

SKU: BCRECP-004558 Categories: ,
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Product Specifications

Product SkuBCRECP-004558
Product DescriptionRecombinant Bovine Transforming growth factor beta-2 proprotein (TGFB2) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 303-414aa. [Accession | P21214].
Uniprot No.P21214
Gene NamesTGFB2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region303-414aa
SpeciesBos taurus (Bovine)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight20.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus.

Biological Context

Subcellular Location: Secreted

Product Specifications

Recombinant Bovine Transforming growth factor beta-2 proprotein (TGFB2), partial is a recombinant protein from Bos taurus (Bovine), expressed in E.coli, covering amino acids 303-414aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 20.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)

Subcellular Location

Secreted

Subunit

Transforming growth factor beta-2: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-2: Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity)

Gene: TGFB2  |  Organism: Bos taurus  |  Synonyms: Milk growth factor

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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