Recombinant Human Transforming growth factor beta-2 proprotein (TGFB2), partial (Active), Homo sapiens (Human), Mammalian cell, Tag-Free, 12.7 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Transforming growth factor beta-2 proprotein (TGFB2), partial (Active)

Recombinant Human Transforming growth factor beta-2 proprotein (TGFB2), partial (Active) — Multifunctional protein that regulates various processes such as angiogenesis and heart development. Purity >95%.

SKU: BCACP-001213 Categories: ,
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Product SKUBCACP-001213
Product DescriptionRecombinant Human Transforming growth factor beta-2 proprotein (TGFB2) protein is expressed from Mammalian cell with Tag-Free. It contains 303-414aa. [Accession | P61812].
Uniprot No.P61812
Gene NamesTGFB2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region303-414aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight12.7 kDa
ActivityThe ED50 as determined by its ability to induce SMAD signaling in 293-Activin A Res cells is 1.3 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesBSC-1 cell growth inhibitor; BSC1 cell growth inhibitor; Cetermin; G-TSF; Glioblastoma-derived T-cell suppressor factor; GTSF; LAP; Latency-associated peptide; MGC116892; MGF; Milk growth factor; Polyergin; TGF-beta-2; TGF-beta2; TGFB2; TGFB2_HUMAN; Transforming growth factor beta 2

Function

Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus.

Product Specifications

Recombinant Human Transforming growth factor beta-2 proprotein (TGFB2), partial (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 303-414aa, with Tag-Free tag, molecular weight 12.7 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: The ED50 as determined by its ability to induce SMAD signaling in 293-Activin A Res cells is 1.3 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Multifunctional protein that regulates various processes such as angiogenesis and heart development (PubMed:22772368, PubMed:22772371). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)

Gene: TGFB2  |  Organism: Homo sapiens

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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