Recombinant Candida albicans pH-regulated antigen PRA1 (PRA1), Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast), Yeast, N-terminal 6xHis-tagged, 33.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Candida albicans pH-regulated antigen PRA1 (PRA1)

Recombinant Candida albicans pH-regulated antigen PRA1 (PRA1) — Cell surface protein involved in the host-parasite interaction during candidal infection. Purity >90%.

SKU: BCRECP-004152 Category:
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Product Specifications

Product SkuBCRECP-004152
Product DescriptionRecombinant Candida albicans pH-regulated antigen PRA1 (PRA1) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 16-299aa. [Accession | P87020].
Uniprot No.P87020
Gene NamesPRA1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region16-299aa
SpeciesCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Tag InfoN-terminal 6xHis-tagged
Molecular weight33.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation.

Biological Context

Subcellular Location: Secreted

Product Specifications

Recombinant Candida albicans pH-regulated antigen PRA1 (PRA1) is a recombinant protein from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast), expressed in Yeast, covering amino acids 16-299aa, with N-terminal 6xHis-tagged tag, molecular weight 33.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Cell surface protein involved in the host-parasite interaction during candidal infection (PubMed:17277107, PubMed:19850343, PubMed:20504767, PubMed:20644161, PubMed:21212281, PubMed:21245270, PubMed:21820180, PubMed:22074954, PubMed:22761575, PubMed:22844116, PubMed:9440517). With MP65, represents a major component of the biofilm matrix (PubMed:17277107). As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation (PubMed:19850343, PubMed:20504767). As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance (PubMed:17277107, PubMed:19850343). Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation and protection from uptake of C.albicans by human macrophages (PubMed:20644161). Also mediates human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2 (PubMed:21212281, PubMed:21245270, PubMed:21820180, PubMed:22844116). Binds zinc from its environment and then reassociates with ZRT1 to acquire this essential metal (PubMed:22761575)

Subcellular Location

Secreted

Subunit

Component of a multiprotein complex of 250 kDa composed of at least HYR1, MP65, and PRA1 (PubMed:17277107). Interacts with host Integrin alpha-M/beta-2 heterodimer (PubMed:17277107). Also binds human factor H (CFH), CFHR1, plasminogen (PLG), complement C3, and C4BPA (PubMed:19850343, PubMed:20644161, PubMed:21212281, PubMed:21245270). Interacts with ZRT101 (PubMed:22761575)

Gene: PRA1  |  Organism: Candida albicans (strain SC5314 / ATCC MYA-2876)  |  Synonyms: 58 kDa fibrinogen-binding mannoprotein
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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