Recombinant Conus marmoreus Chi-conotoxin MrIA, Conus marmoreus (Marble cone), E.coli, N-terminal 6xHis-KSI-tagged, 16.7kDa, purity >95% as determined by SDS-PAGE.

Recombinant Conus marmoreus Chi-conotoxin MrIA

Recombinant Conus marmoreus Chi-conotoxin MrIA — Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2). Purity >95%.

SKU: BCRECP-003645 Category:
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Product Specifications

Product SkuBCRECP-003645
Product DescriptionRecombinant Conus marmoreus Chi-conotoxin MrIA Protein is expressed from E.coli with N-terminal 6xHis-KSI-tagged. It contains 49-61aa. [Accession | P58808].
Uniprot No.P58808
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region49-61aa
SpeciesConus marmoreus (Marble cone)
Tag InfoN-terminal 6xHis-KSI-tagged
Molecular weight16.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2). Activity has been described on both human (inhibition of norepinephrine uptake is IC(50)=1.26 uM) and rat (pIC(50)=6.21 corresponding IC(50)=0.16 uM) transporters. Acts as a reversible non-competitive inhibitor.

Product Specifications

Recombinant Conus marmoreus Chi-conotoxin MrIA is a recombinant protein, expressed in E.coli, covering amino acids 49-61aa, with N-terminal 6xHis-KSI-tagged tag, molecular weight 16.7kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2) (PubMed:11528421, PubMed:12837768, PubMed:12885787, PubMed:16154696). Activity has been described on both human (inhibition of norepinephrine uptake is IC(50)=1.26 uM) and rat (pIC(50)=6.21 corresponding IC(50)=0.16 uM) transporters (PubMed:11528421, PubMed:12885787). Acts as a reversible non-competitive inhibitor (PubMed:11528421)

Organism: Conus marmoreus

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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