Recombinant Conus marmoreus Mu-conotoxin MrVIB, Conus marmoreus (Marble cone), E.coli, N-terminal GST-tagged, 30.3kDa, purity >85% as determined by SDS-PAGE.

Recombinant Conus marmoreus Mu-conotoxin MrVIB

Recombinant Conus marmoreus Mu-conotoxin MrVIB — MuO-conotoxins are gating-modifier toxins that inhibit sodium current by trapping the domain II voltage sensor in the closed position to prevent opening of the sodium channel. Purity >85%.

SKU: BCRECP-003739 Category:
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Product Specifications

Product SkuBCRECP-003739
Product DescriptionRecombinant Conus marmoreus Mu-conotoxin MrVIB Protein is expressed from E.coli with N-terminal GST-tagged. It contains 52-82aa. [Accession | Q26443].
Uniprot No.Q26443
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region52-82aa
SpeciesConus marmoreus (Marble cone)
Tag InfoN-terminal GST-tagged
Molecular weight30.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

MuO-conotoxins are gating-modifier toxins that inhibit sodium current by trapping the domain II voltage sensor in the closed position to prevent opening of the sodium channel. This toxin has a preference for Nav1.4/SCN4A over Nav1.2/SCN2A sodium channels. It blocks Nav channels by interacting mainly with the C-terminal part of the pore loop of domain-3.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed by the venom duct

Product Specifications

Recombinant Conus marmoreus Mu-conotoxin MrVIB is a recombinant protein from Conus marmoreus (Marble cone), expressed in E.coli, covering amino acids 52-82aa, with N-terminal GST-tagged tag, molecular weight 30.3kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

MuO-conotoxins are gating-modifier toxins that inhibit sodium current by trapping the domain II voltage sensor in the closed position to prevent opening of the sodium channel. This toxin has a preference for Nav1.4/SCN4A over Nav1.2/SCN2A sodium channels. It blocks Nav channels by interacting mainly with the C-terminal part of the pore loop of domain-3. It also blocks fast-inactivating calcium current. Blocks Nav1.8/SCN10A sodium channels and has potent and long-lasting local anesthetic effects. It can also block propagation of action potentials in A- and C-fibers in sciatic nerve as well as skeletal muscle in isolated preparations

Subcellular Location

Secreted

Tissue Specificity

Expressed by the venom duct

Organism: Conus marmoreus  |  Synonyms: CGX-1002

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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