Recombinant Dog B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active), Canis lupus familiaris (Dog) (Canis familiaris), Mammalian cell, C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions), 34.4 kDa, purity >90% as determined by SEC-HPLC.
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Recombinant Dog B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active)

Recombinant Dog B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) — B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Purity >90%.

SKU: BCACP-000198 Categories: , ,
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Product SKUBCACP-000198
Product DescriptionRecombinant Canis familiaris B-lymphocyte antigen CD20 (MS4A1)-VLPs protein is expressed from Mammalian cell with C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions). It contains 1-297aa. [Accession | Q3C2E2].
Uniprot No.Q3C2E2
Gene NamesMS4A1
PurityGreater than 90% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region1-297aa
SpeciesCanis lupus familiaris (Dog) (Canis familiaris)
Tag InfoC-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Molecular weight34.4 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CD44 at 2 μg/mL can bind Anti-CD44 monoclonal antibody , the EC50 is 64.18-90.91 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(Membrane-spanning 4-domains subfamily A member 1)(CD antigen CD20)

Function

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Cell membrane (Lipid-anchor)
Tissue Specificity: Expressed in PBMCs and lymph node from healthy dogs, in B-cells of canine lymphoma, but not in T-cell lymphoma cells and non-T and non-B-cell lymphoma cells

Product Specifications

Recombinant Dog B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) is a recombinant protein from Canis lupus familiaris (Dog) (Canis familiaris), expressed in Mammalian cell, covering amino acids 1-297aa, with C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions) tag, molecular weight 34.4 kDa, purity Greater than 90% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CD44 at 2 μg/mL can bind Anti-CD44 monoclonal antibody , the EC50 is 64.18-90.91 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR

Subcellular Location

Cell membrane (Multi-pass membrane protein); Cell membrane (Lipid-anchor)

Tissue Specificity

Expressed in PBMCs and lymph node from healthy dogs, in B-cells of canine lymphoma, but not in T-cell lymphoma cells and non-T and non-B-cell lymphoma cells

Subunit

Forms homotetramers. Interacts with the heavy and light chains of cell surface IgM, the antigen-binding components of the BCR

Gene: MS4A1  |  Organism: Canis lupus familiaris  |  Synonyms: Membrane-spanning 4-domains subfamily A member 1

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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