Recombinant Human B-lymphocyte antigen CD20 (MS4A1)-Detergent (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 34.4 kDa, purity >85% as determined by SDS-PAGE.
,

Recombinant Human B-lymphocyte antigen CD20 (MS4A1)-Detergent (Active)

Recombinant Human B-lymphocyte antigen CD20 (MS4A1)-Detergent (Active) — B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Purity >85%.

SKU: BCACP-000311 Categories: ,
Online Inquiry →
Product SKUBCACP-000311
Product DescriptionRecombinant Human B-lymphocyte antigen CD20 (MS4A1)-Detergent protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 1-297aa. [Accession | P11836].
Uniprot No.P11836
Gene NamesMS4A1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region1-297aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight34.4 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis LRRC15 at 2 μg/mL on an Nickel Coated plate can bind Anti-LRRC15 recombinant antibody . The EC50 is 4.100-5.074 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesB-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD antigen CD20

Function

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Cell membrane (Lipid-anchor)
Tissue Specificity: Expressed on B-cells
Disease Association: Immunodeficiency, common variable, 5 (CVID5) : A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human B-lymphocyte antigen CD20 (MS4A1)-Detergent (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 1-297aa, with C-terminal 10xHis-tagged tag, molecular weight 34.4 kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis LRRC15 at 2 μg/mL on an Nickel Coated plate can bind Anti-LRRC15 recombinant antibody . The EC50 is 4.100-5.074 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739)

Subcellular Location

Cell membrane (Multi-pass membrane protein); Cell membrane (Lipid-anchor)

Disease Association

Immunodeficiency, common variable, 5 (CVID5) : A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed on B-cells

Subunit

Forms homotetramers (PubMed:18474602, PubMed:7684739). Interacts with the heavy and light chains of cell surface IgM, the antigen-binding components of the BCR (PubMed:18474602)

Gene: MS4A1  |  Organism: Homo sapiens  |  Synonyms: B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

Shopping Cart
Scroll to Top