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Recombinant Drosophila melanogaster Nuclear RNA export factor 2 (nxf2), partial

Recombinant Drosophila melanogaster Nuclear RNA export factor 2 (nxf2), partial — May be involved in the export of mRNA from the nucleus to the cytoplasm. Purity >85%.

SKU: BCRECP-003920 Category:
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Product Specifications

Product SkuBCRECP-003920
Product DescriptionRecombinant Drosophila melanogaster Nuclear RNA export factor 2 (nxf2) Protein is expressed from Baculovirus with C-terminal 6xHis-tagged. It contains 573-841aa. [Accession | Q9VV73].
Uniprot No.Q9VV73
Gene Namesnxf2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemBaculovirus
Expression Region573-841aa
SpeciesDrosophila melanogaster (Fruit fly)
Tag InfoC-terminal 6xHis-tagged
Molecular weight33.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

May be involved in the export of mRNA from the nucleus to the cytoplasm. In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing. On recruitment to a target transcript, interacts with single stranded RNA, thereby anchoring the complex via the nascent target transcript to chromatin and allowing Panx to recruit silencing effectors to establishing repressive heterochromatin at transposon loci.

Biological Context

Subcellular Location: Cytoplasm; Nucleus; Nucleus, nucleoplasm
Tissue Specificity: Expressed in female gonads (at protein level). Expressed ubiquitously

Product Specifications

Recombinant Drosophila melanogaster Nuclear RNA export factor 2 (nxf2), partial is a recombinant protein from Drosophila melanogaster (Fruit fly), expressed in Baculovirus, covering amino acids 573-841aa, with C-terminal 6xHis-tagged tag, molecular weight 33.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

May be involved in the export of mRNA from the nucleus to the cytoplasm (PubMed:11780633). In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). On recruitment to a target transcript, interacts with single stranded RNA, thereby anchoring the complex via the nascent target transcript to chromatin and allowing Panx to recruit silencing effectors to establishing repressive heterochromatin at transposon loci (PubMed:31368590, PubMed:31384064, PubMed:31570835). Does not affect piRNA biogenesis (PubMed:31384064). The interaction with Panx stabilizes the nuclear protein complex (PubMed:31384064). Does not bind nucleoporins, but regulates sbr/Nxf1 binding to nucleoporins and, indirectly, transposon exports (PubMed:31384064, PubMed:31570835)

Subcellular Location

Cytoplasm; Nucleus; Nucleus, nucleoplasm

Tissue Specificity

Expressed in female gonads (at protein level) (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). Expressed ubiquitously (PubMed:11780633)

Subunit

In the ovaries, part of a complex composed of at least Panx, nxf2, piwi and Nxt1 (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). The complex is knowns as Panx-induced cotranscriptional silencing (PICTS) complex, Panx-nxf2-dependent TAP/p15 silencing (Pandas complex), SFiNX (silencing factor interacting nuclear export variant) or piwi-Panx-nxf2-p15 (PPNP) complex (PubMed:31219034, PubMed:31368590, PubMed:31384064, PubMed:31570835). Interacts (via TAP-C domain) with Panx (via NIR region); the interaction is direct (PubMed:31219034, PubMed:31368590, PubMed:31570835). Interacts (via NTF2 domain) with Nxt1; the interaction is direct and prevents Nxt1 binding to nucleoporins (PubMed:31368590). Interacts with sbr/Nxf1 (PubMed:31570835)

Gene: nxf2  |  Organism: Drosophila melanogaster
Key Publications

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