Recombinant Epstein-Barr virus Latent membrane protein 1 (LMP1), partial, Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4), Yeast, N-terminal 10xHis-tagged, 21.3kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Epstein-Barr virus Latent membrane protein 1 (LMP1), partial

Recombinant Epstein-Barr virus Latent membrane protein 1 (LMP1), partial — Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Purity >90%.

SKU: BCRECP-003275 Categories: ,
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Product Specifications

Product SkuBCRECP-003275
Product DescriptionRecombinant Epstein-Barr virus Latent membrane protein 1 (LMP1) Protein is expressed from Yeast with N-terminal 10xHis-tagged. It contains 185-366aa. [Accession | P0C741].
Uniprot No.P0C741
Gene NamesLMP1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region185-366aa
SpeciesEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
Tag InfoN-terminal 10xHis-tagged
Molecular weight21.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells.

Product Specifications

Recombinant Epstein-Barr virus Latent membrane protein 1 (LMP1), partial is a recombinant protein, expressed in Yeast, covering amino acids 185-366aa, with N-terminal 10xHis-tagged tag, molecular weight 21.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. Also inhibits host IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity by interacting with and inhibiting host TYK2. Induces SUMO expression during viral latency thereby dysregulating the host sumoylation processes

Gene: LMP1  |  Organism: Human herpesvirus 4 (strain GD1)

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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