Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A), Cavia porcellus (Guinea pig), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 26.2kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A)

Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A) — Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Purity >90%.

SKU: BCRECP-003146 Categories: ,
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Product Specifications

Product SkuBCRECP-003146
Product DescriptionRecombinant Guinea pig Interleukin-23 subunit alpha (IL23A) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 20-189aa. [Accession | Q6LA37].
Uniprot No.Q6LA37
Gene NamesIL23A
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region20-189aa
SpeciesCavia porcellus (Guinea pig)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight26.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A.

Biological Context

Subcellular Location: Secreted

Product Specifications

Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A) is a recombinant protein from Cavia porcellus (Guinea pig), expressed in E.coli, covering amino acids 20-189aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 26.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells

Subcellular Location

Secreted

Subunit

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23. Interacts with IL23R; this interaction enables recruitment of IL12RB1

Gene: IL23A  |  Organism: Cavia porcellus  |  Synonyms: Interleukin-23 subunit p19

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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