Recombinant Human adenovirus C serotype 2 Early E3 18.5 kDa glycoprotein, partial, Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 20.0kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human adenovirus C serotype 2 Early E3 18.5 kDa glycoprotein, partial

Recombinant Human adenovirus C serotype 2 Early E3 18.5 kDa glycoprotein, partial — Binds and retains class I heavy chains in the endoplasmic reticulum during the early period of virus infection, thereby impairing their transport to the cell surface. Purity >90%.

SKU: BCRECP-003531 Categories: ,
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Product Specifications

Product SkuBCRECP-003531
Product DescriptionRecombinant Human adenovirus C serotype 2 Early E3 18.5 kDa glycoprotein, partial Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 18-123aa. [Accession | P68978].
Uniprot No.P68978
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region18-123aa
SpeciesHuman adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight20.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Binds and retains class I heavy chains in the endoplasmic reticulum during the early period of virus infection, thereby impairing their transport to the cell surface. Also delays the expression of class I alleles that it cannot affect by direct retention.

Product Specifications

Recombinant Human adenovirus C serotype 2 Early E3 18.5 kDa glycoprotein, partial — Binds and retains class I heavy chains in the endoplasmic reticulum during the early period of virus infection, thereby impairing their transport to the cell surface. Purity >90%. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Binds and retains class I heavy chains in the endoplasmic reticulum during the early period of virus infection, thereby impairing their transport to the cell surface. Also delays the expression of class I alleles that it cannot affect by direct retention. Binds transporters associated with antigen processing (TAP) and acts as a tapasin inhibitor, preventing class I/TAP association. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes (By similarity)

Subcellular Location

Host endoplasmic reticulum membrane (Single-pass type I membrane protein)

Organism: Human adenovirus C serotype 2  |  Synonyms: E3-19K; E3gp 19 kDa; GP19K

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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