Recombinant Human adenovirus C serotype 5 Hexon protein (L3) (T273A), partial

Function

Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus

Subcellular Location

Virion; Host nucleus

Subunit

Homotrimer. Interacts with the capsid vertex protein; this interaction binds the peripentonal hexons to the neighboring penton base. Interacts with the hexon-linking protein VIII; this interaction tethers the hexons surrounding the penton to those situated in the central plate of the facet (PubMed:28978703, PubMed:30121295). Interacts with the hexon-interlacing protein IX; this interaction lashes the hexons together (PubMed:28978703, PubMed:30121295). Interacts with pre-protein VI; this interaction probably allows nuclear import of hexon trimers and possibly pre-capsid assembly (PubMed:14633984). Interacts with endosome lysis protein (PubMed:28978703). Interacts with pVIn (PubMed:28978703, PubMed:30121295). Interacts with pVIIn2 (PubMed:28978703). Interacts with host dyneins DYNC1LI1 and DYNC1I2; this interaction might be involved in intracellular microtubule-dependent transport of incoming viral capsid (PubMed:20006841). Interacts with the shutoff protein; this interaction allows folding and formation of hexons trimers. Interacts with host NUP214 (via N-terminus); this interaction might be essential for the release of the virus genome to the nucleus (By similarity) (PubMed:25410864). Interacts with host LTF/Lactoferrin (via N-terminus); this interaction seems to be part of the mechanisms of cellular entry by the virus (PubMed:38323814). Interacts with host blood coagulation factor F10 (via Gla domain); this interaction allows the virus to be shielded from its host immune system (PubMed:39528527)

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