Recombinant Human Annexin A2 (ANXA2), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 42.5kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Annexin A2 (ANXA2)

Recombinant Human Annexin A2 (ANXA2) — (Microbial infection) Binds M. Purity >85%.

SKU: BCRECP-000086 Category:
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Product Specifications

Product SkuBCRECP-000086
Product DescriptionRecombinant Human Annexin A2 (ANXA2) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 2-339aa. [Accession | P07355].
Uniprot No.P07355
Gene NamesANXA2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-339aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight42.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

(Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen.

Biological Context

Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane; Melanosome
Disease Association: [Increased expression of ANXA2 is associated with hepatocellular carcinoma tumor progression]

Product Specifications

Recombinant Human Annexin A2 (ANXA2) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-339aa, with N-terminal 6xHis-tagged tag, molecular weight 42.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

(Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen

Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane; Melanosome

Disease Association

[Increased expression of ANXA2 is associated with hepatocellular carcinoma tumor progression]

Subunit

(Microbial infection) Interacts with M.pneumoniae CARDS toxin; CARDS probably uses this protein as a receptor. A portion of internalized CARDS remains associated with intracellular annexin 2

Gene: ANXA2  |  Organism: Homo sapiens  |  Synonyms: Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; Protein I; p36
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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