Recombinant Human Annexin A2 (ANXA2)

Recombinant Human Annexin A2 (ANXA2) — (Microbial infection) Binds M. Purity >90%.

SKU: BCRECP-000085 Category:

Product Specifications

Product SkuBCRECP-000085
Product DescriptionRecombinant Human Annexin A2 (ANXA2) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 2-339aa. [Accession | P07355].
Uniprot No.P07355
Gene NamesANXA2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-339aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight54.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

(Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen.

Biological Context

Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane; Melanosome
Disease Association: [Increased expression of ANXA2 is associated with hepatocellular carcinoma tumor progression]

Product Specifications

Recombinant Human Annexin A2 (ANXA2) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-339aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 54.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Protein Biology

Function

(Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen

Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane; Melanosome

Disease Association

[Increased expression of ANXA2 is associated with hepatocellular carcinoma tumor progression]

Subunit

(Microbial infection) Interacts with M.pneumoniae CARDS toxin; CARDS probably uses this protein as a receptor. A portion of internalized CARDS remains associated with intracellular annexin 2

Gene: ANXA2  |  Organism: Homo sapiens  |  Synonyms: Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; Protein I; p36
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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