Recombinant Human B-cell CLL/lymphoma 9 protein (BCL9), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged and C-terminal 6xHis-tagged, 26.7kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human B-cell CLL/lymphoma 9 protein (BCL9), partial

Recombinant Human B-cell CLL/lymphoma 9 protein (BCL9), partial — Involved in signal transduction through the Wnt pathway. Purity >85%.

SKU: BCRECP-000156 Category:
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Product Specifications

Product SkuBCRECP-000156
Product DescriptionRecombinant Human B-cell CLL/lymphoma 9 protein (BCL9) Protein is expressed from E.coli with N-terminal 6xHis-tagged and C-terminal 6xHis-tagged. It contains 174-396aa. [Accession | O00512].
Uniprot No.O00512
Gene NamesBCL9
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region174-396aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged and C-terminal 6xHis-tagged
Molecular weight26.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity.

Biological Context

Subcellular Location: Nucleus
Tissue Specificity: Detected at low levels in thymus, prostate, testis, ovary and small intestine, and at lower levels in spleen, colon and blood
Disease Association: [A chromosomal aberration involving BCL9 is found in a patient with precursor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies]

Product Specifications

Recombinant Human B-cell CLL/lymphoma 9 protein (BCL9), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 174-396aa, with N-terminal 6xHis-tagged and C-terminal 6xHis-tagged tag, molecular weight 26.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity)

Subcellular Location

Nucleus

Disease Association

[A chromosomal aberration involving BCL9 is found in a patient with precursor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies]

Tissue Specificity

Detected at low levels in thymus, prostate, testis, ovary and small intestine, and at lower levels in spleen, colon and blood

Subunit

Binds to beta-catenin (CTNNB1), PYGO1 and PYGO2; the interaction with PYGO1 increases PYGO1 affinity to histone H3 methylated at 'Lys 4'

Gene: BCL9  |  Organism: Homo sapiens  |  Synonyms: Protein legless homolog
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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