Recombinant Human B-cell differentiation antigen CD72 (CD72), partial, Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 57.0kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human B-cell differentiation antigen CD72 (CD72), partial

Recombinant Human B-cell differentiation antigen CD72 (CD72), partial — Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Purity >95%.

SKU: BCRECP-000310 Categories: ,
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Product Specifications

Product SkuBCRECP-000310
Product DescriptionRecombinant Human B-cell differentiation antigen CD72 (CD72) Protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 117-359aa. [Accession | P21854].
Uniprot No.P21854
Gene NamesCD72
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region117-359aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight57.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling.

Biological Context

Subcellular Location: Membrane (Single-pass type II membrane protein)
Tissue Specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells

Product Specifications

Recombinant Human B-cell differentiation antigen CD72 (CD72), partial is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 117-359aa, with C-terminal hFc1-tagged tag, molecular weight 57.0kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis

Subcellular Location

Membrane (Single-pass type II membrane protein)

Tissue Specificity

Pre-B-cells and B-cells but not terminally differentiated plasma cells

Subunit

Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1

Gene: CD72  |  Organism: Homo sapiens  |  Synonyms: Lyb-2

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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