Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial, Mus musculus (Mouse), Mammalian cell, N-terminal hFc-tagged, 54.3kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial

Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial — Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Purity >95%.

SKU: BCRECP-002330 Categories: ,
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Product Specifications

Product SkuBCRECP-002330
Product DescriptionRecombinant Mouse B-cell differentiation antigen CD72 (Cd72) Protein is expressed from Mammalian cell with N-terminal hFc-tagged. It contains 117-354aa. [Accession | P21855].
Uniprot No.P21855
Gene NamesCd72
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region117-354aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal hFc-tagged
Molecular weight54.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling.

Biological Context

Subcellular Location: Membrane (Single-pass type II membrane protein)
Tissue Specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells

Product Specifications

Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial is a recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell, covering amino acids 117-354aa, with N-terminal hFc-tagged tag, molecular weight 54.3kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions (PubMed:10549631). Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling (PubMed:27810925). Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling (PubMed:9590210). Acts also as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis (PubMed:24950378, PubMed:9723705)

Subcellular Location

Membrane (Single-pass type II membrane protein)

Tissue Specificity

Pre-B-cells and B-cells but not terminally differentiated plasma cells

Subunit

Homodimer; disulfide-linked. Associates with CD5 (PubMed:24950378, PubMed:9723705). Interacts (tyrosine phosphorylated) with PTPN6/SHP-1

Gene: Cd72  |  Organism: Mus musculus  |  Synonyms: Lyb-2; Lymphocyte antigen 32
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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