Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial, Mus musculus (Mouse), Mammalian cell, N-terminal hFc-tagged, 54.3kDa, purity >95% as determined by SDS-PAGE.
,

Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial

Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial — Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Purity >95%.

SKU: BCRECP-002330 Categories: ,
Online Inquiry →

Product Specifications

Product SkuBCRECP-002330
Product DescriptionRecombinant Mouse B-cell differentiation antigen CD72 (Cd72) Protein is expressed from Mammalian cell with N-terminal hFc-tagged. It contains 117-354aa. [Accession | P21855].
Uniprot No.P21855
Gene NamesCd72
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region117-354aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal hFc-tagged
Molecular weight54.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling.

Biological Context

Subcellular Location: Membrane (Single-pass type II membrane protein)
Tissue Specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells

Product Specifications

Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial is a recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell, covering amino acids 117-354aa, with N-terminal hFc-tagged tag, molecular weight 54.3kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions (PubMed:10549631). Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling (PubMed:27810925). Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling (PubMed:9590210). Acts also as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis (PubMed:24950378, PubMed:9723705)

Subcellular Location

Membrane (Single-pass type II membrane protein)

Tissue Specificity

Pre-B-cells and B-cells but not terminally differentiated plasma cells

Subunit

Homodimer; disulfide-linked. Associates with CD5 (PubMed:24950378, PubMed:9723705). Interacts (tyrosine phosphorylated) with PTPN6/SHP-1

Gene: Cd72  |  Organism: Mus musculus  |  Synonyms: Lyb-2; Lymphocyte antigen 32
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

Shopping Cart
Scroll to Top