Recombinant Human C-C chemokine receptor type 2 (CCR2) (Active), Homo sapiens (Human), in vitro E.coli expression system, Tag type will be determined during the manufacturing process. The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially., 45.4 kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human C-C chemokine receptor type 2 (CCR2) (Active)

Recombinant Human C-C chemokine receptor type 2 (CCR2) (Active) — recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system. Purity >85%.

SKU: BCACP-000047 Categories: ,
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Product SKUBCACP-000047
Product DescriptionRecombinant Human C-C chemokine receptor type 2 (CCR2) protein is expressed from in vitro E.coli expression system with Tag type will be determined during the manufacturing process. The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.. It contains 1-374aa. [Accession | P41597].
Uniprot No.P41597
Gene NamesCCR2
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-374aa
SpeciesHomo sapiens (Human)
Tag InfoTag type will be determined during the manufacturing process. The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Molecular weight45.4 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized CCL5 at 2 μg/ml can bind human GPD1L, the EC50 of human GPD1L protein is 47.34-66.33 μg/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCCR2; CMKBR2; C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD antigen CD192

Function

(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Expressed by monocytes and IL2-activated NK cells. Abundantly expressed on CD14+/CD16- monocytes and weakly on CD14+/CD16+ monocytes, type 2 dendritic cells (DCs) and plasmacytoid DCs (at protein level)
Disease Association: Polycystic lung disease (PCLUD) : An autosomal recessive disease characterized by pulmonary alveolar proteinosis, marked peribronchovascular and parenchymal lymphocytosis, peribronchiolar pulmonary fibrosis, progressive diffuse parenchymal lung cyst formation and enlargement, progressive obstructive airflow limitation, and recurrent secondary infections. Additional features may include digital clubbing, allergies, and atopic dermatitis. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human C-C chemokine receptor type 2 (CCR2) (Active) is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-374aa, with Tag type will be determined during the manufacturing process. The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. tag, molecular weight 45.4 kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized CCL5 at 2 μg/ml can bind human GPD1L, the EC50 of human GPD1L protein is 47.34-66.33 μg/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Disease Association

Polycystic lung disease (PCLUD) : An autosomal recessive disease characterized by pulmonary alveolar proteinosis, marked peribronchovascular and parenchymal lymphocytosis, peribronchiolar pulmonary fibrosis, progressive diffuse parenchymal lung cyst formation and enlargement, progressive obstructive airflow limitation, and recurrent secondary infections. Additional features may include digital clubbing, allergies, and atopic dermatitis. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed by monocytes and IL2-activated NK cells (PubMed:9058802). Abundantly expressed on CD14+/CD16- monocytes and weakly on CD14+/CD16+ monocytes, type 2 dendritic cells (DCs) and plasmacytoid DCs (at protein level) (PubMed:38157855)

Subunit

(Microbial infection) Interacts with Kaposi virus protein vCCL2

Gene: CCR2  |  Organism: Homo sapiens  |  Synonyms: Monocyte chemoattractant protein 1 receptor
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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