Recombinant Human C-C motif chemokine 21 protein (CCL21), Homo sapiens (Human), E.Coli, Tag-Free, 12.2 kDa, purity >>95% as determined by SDS-PAGE.
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Recombinant Human C-C motif chemokine 21 protein (CCL21)

Recombinant Human C-C motif chemokine 21 protein (CCL21) — Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. Purity >95%.

SKU: BCACP-000770 Categories: ,
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Product SKUBCACP-000770
Product DescriptionRecombinant Human C-C motif chemokine 21 protein (CCL21) protein is expressed from E.Coli with Tag-Free. It contains 24-134aa. [Accession | O00585].
Uniprot No.O00585
Gene NamesCCL21
Purity>95% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region24-134aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight12.2 kDa
ActivityFully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration of 50-100 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names6Ckine; Beta chemokine exodus 2; Beta-chemokine exodus-2; C C motif chemokine ligand 21; C-C motif chemokine 21; CCL21; CCL21_HUMAN; Chemokine (C-C motif) ligand 21; Chemokine CC motif ligand 21; CKb9; ECL; Efficient Chemoattractant for Lymphocytes; SCYA21; Secondary lymphoid tissue chemokine; Secondary lymphoid-tissue chemokine; SLC; Small inducible cytokine A21 ; Small inducible cytokine subfamily A (Cys-Cys); member 21; Small-inducible cytokine A21; TCA4; UNQ784/PRO1600

Function

Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. Binds to chemokine receptor CCR7. Does not bind to chemokine receptor CXCR3.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen

Product Specifications

Recombinant Human C-C motif chemokine 21 protein (CCL21) is a recombinant protein from Homo sapiens (Human), expressed in E.Coli, covering amino acids 24-134aa, with Tag-Free tag, molecular weight 12.2 kDa, purity >95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration of 50-100 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (PubMed:23341447). Binds to chemokine receptor CCR7 (PubMed:9507024). Does not bind to chemokine receptor CXCR3 (PubMed:10201891). Binds to G protein-coupled receptor GPR174 (By similarity). Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs

Subcellular Location

Secreted

Tissue Specificity

Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen

Subunit

Monomer PubMed:22221265. Interacts with PDPN; relocalizes PDPN to the basolateral membrane (PubMed:14978162). Interacts with TNFAIP6 (via Link domain) PubMed:27044744

Gene: CCL21  |  Organism: Homo sapiens  |  Synonyms: 6Ckine; Beta-chemokine exodus-2; Secondary lymphoid-tissue chemokine; Small-inducible cytokine A21
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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