Recombinant Human C-X-C chemokine receptor type 2 (CXCR2)-VLPs (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 42.2 kDa, purity >VLPs
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Recombinant Human C-X-C chemokine receptor type 2 (CXCR2)-VLPs (Active)

Recombinant Human C-X-C chemokine receptor type 2 (CXCR2)-VLPs (Active) — Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Purity VLPs.

SKU: BCACP-000542 Categories: , ,
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Product SKUBCACP-000542
Product DescriptionRecombinant Human C-X-C chemokine receptor type 2 (CXCR2)-VLPs protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 1-360aa. [Accession | P25025].
Uniprot No.P25025
Gene NamesCXCR2
PurityVLPs
Expression SystemMammalian cell
Expression Region1-360aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight42.2 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ITGAV&ITGB6 at 2 μg/mL can bind Macaca mulatta TGFB1. The EC50 is 8.899-14.82 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesC-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD antigen CD182

Function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Disease Association: WHIM syndrome 2 (WHIMS2) : An autosomal recessive form of WHIM syndrome, a primary immunodeficiency disorder characterized by warts, hypogammaglobulinemia, infections, and myelokathexis. Myelokathexis is a unique form of non-cyclic severe congenital neutropenia caused by accumulation of mature and degenerating neutrophils in the bone marrow. Monocytopenia and lymphopenia, especially B lymphopenia, also commonly occur. There is significant phenotypic variation among patients, such that some individuals may have an incomplete form of the disorder in which one or more of the classic tetrad features are not present. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human C-X-C chemokine receptor type 2 (CXCR2)-VLPs (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 1-360aa, with C-terminal 10xHis-tagged tag, molecular weight 42.2 kDa, purity VLPs. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ITGAV&ITGB6 at 2 μg/mL can bind Macaca mulatta TGFB1. The EC50 is 8.899-14.82 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (PubMed:1891716). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Disease Association

WHIM syndrome 2 (WHIMS2) : An autosomal recessive form of WHIM syndrome, a primary immunodeficiency disorder characterized by warts, hypogammaglobulinemia, infections, and myelokathexis. Myelokathexis is a unique form of non-cyclic severe congenital neutropenia caused by accumulation of mature and degenerating neutrophils in the bone marrow. Monocytopenia and lymphopenia, especially B lymphopenia, also commonly occur. There is significant phenotypic variation among patients, such that some individuals may have an incomplete form of the disorder in which one or more of the classic tetrad features are not present. [The disease may be caused by variants affecting the gene represented in this entry]

Subunit

Interacts with IL8 (PubMed:1891716). Interacts with GNAI2 (PubMed:8662698)

Gene: CXCR2  |  Organism: Homo sapiens  |  Synonyms: CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8 receptor type 2
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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