Recombinant Human Calcitonin gene-related peptide 1 (CALCA), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-GST-tagged, 35.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Calcitonin gene-related peptide 1 (CALCA), partial

Recombinant Human Calcitonin gene-related peptide 1 (CALCA), partial — CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Purity >90%.

SKU: BCRECP-000218 Category:
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Product Specifications

Product SkuBCRECP-000218
Product DescriptionRecombinant Human Calcitonin gene-related peptide 1 (CALCA) Protein is expressed from E.coli with N-terminal 6xHis-GST-tagged. It contains 83-119aa. [Accession | P06881].
Uniprot No.P06881
Gene NamesCALCA
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region83-119aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-GST-tagged
Molecular weight35.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed in spinal cord

Product Specifications

Recombinant Human Calcitonin gene-related peptide 1 (CALCA), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 83-119aa, with N-terminal 6xHis-GST-tagged tag, molecular weight 35.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:33602864, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed:3492492). It also elevates platelet cAMP (PubMed:1318039). CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770)

Subcellular Location

Secreted

Tissue Specificity

Expressed in spinal cord

Gene: CALCA  |  Organism: Homo sapiens  |  Synonyms: Alpha-type CGRP; Calcitonin gene-related peptide I
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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