Recombinant Human Calcitonin gene-related peptide 1 (CALCA), partial, Homo sapiens (Human), Yeast, N-terminal 6xHis-sumostar-tagged, 16.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Calcitonin gene-related peptide 1 (CALCA), partial

Recombinant Human Calcitonin gene-related peptide 1 (CALCA), partial — CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Purity >90%.

SKU: BCRECP-000221 Category:
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Product Specifications

Product SkuBCRECP-000221
Product DescriptionRecombinant Human Calcitonin gene-related peptide 1 (CALCA) Protein is expressed from Yeast with N-terminal 6xHis-sumostar-tagged. It contains 83-119aa. [Accession | P06881].
Uniprot No.P06881
Gene NamesCALCA
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region83-119aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-sumostar-tagged
Molecular weight16.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed in spinal cord

Product Specifications

Recombinant Human Calcitonin gene-related peptide 1 (CALCA), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 83-119aa, with N-terminal 6xHis-sumostar-tagged tag, molecular weight 16.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:33602864, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed:3492492). It also elevates platelet cAMP (PubMed:1318039). CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770)

Subcellular Location

Secreted

Tissue Specificity

Expressed in spinal cord

Gene: CALCA  |  Organism: Homo sapiens  |  Synonyms: Alpha-type CGRP; Calcitonin gene-related peptide I
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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