Function
(Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity.
Biological Context
Subcellular Location: Cytoplasm, cytoskeleton, spindle; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cell projection, cilium, flagellum
Disease Association: Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) : An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT4 inheritance is autosomal dominant. [The disease is caused by variants affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4] | Long QT syndrome 14 (LQT14) : A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Calmodulin (CALM1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-149aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 32.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
