Recombinant Human Calmodulin (CALM1), Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 32.7kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Calmodulin (CALM1)

Recombinant Human Calmodulin (CALM1) — (Microbial infection) Required for C. Purity >85%.

SKU: BCRECP-000222 Category:
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Product Specifications

Product SkuBCRECP-000222
Product DescriptionRecombinant Human Calmodulin (CALM1) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 2-149aa. [Accession | P0DP23].
Uniprot No.P0DP23
Gene NamesCALM1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-149aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight32.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

(Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity.

Biological Context

Subcellular Location: Cytoplasm, cytoskeleton, spindle; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cell projection, cilium, flagellum
Disease Association: Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) : An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT4 inheritance is autosomal dominant. [The disease is caused by variants affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4] | Long QT syndrome 14 (LQT14) : A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Calmodulin (CALM1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-149aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 32.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

(Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity

Subcellular Location

Cytoplasm, cytoskeleton, spindle; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cell projection, cilium, flagellum

Disease Association

Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) : An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT4 inheritance is autosomal dominant. [The disease is caused by variants affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4] | Long QT syndrome 14 (LQT14) : A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

(Microbial infection) Interacts with S.flexneri OspC1 and OspC3 (PubMed:35568036, PubMed:36624349). S.flexneri OspC1 and OspC3 interact specifically with the apo form of calmodulin and prevents calcium-binding (PubMed:35568036)

Gene: CALM1  |  Organism: Homo sapiens
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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