Recombinant Human Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1), partial, Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 18.4kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1), partial

Recombinant Human Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1), partial — recombinant protein from Homo sapiens (Human), expressed in Yeast. Purity >90%.

SKU: BCRECP-000422 Categories: ,
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Product Specifications

Product SkuBCRECP-000422
Product DescriptionRecombinant Human Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 1354-1500aa. [Accession | P31327].
Uniprot No.P31327
Gene NamesCPS1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1354-1500aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight18.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.

Biological Context

Subcellular Location: Mitochondrion; Nucleus, nucleolus; Cell membrane (Peripheral membrane protein)
Tissue Specificity: Primarily in the liver and small intestine
Disease Association: Carbamoyl phosphate synthetase 1 deficiency (CPS1D) : An autosomal recessive disorder of the urea cycle causing hyperammonemia. It can present as a devastating metabolic disease dominated by severe hyperammonemia in neonates or as a more insidious late-onset condition, generally manifesting as life-threatening hyperammonemic crises under catabolic situations. Clinical features include protein intolerance, intermittent ataxia, seizures, lethargy, developmental delay and intellectual disability. [The disease is caused by variants affecting the gene represented in this entry] | [CPS1 protein variants might influence the availability of precursors for nitric oxide (NO) synthesis and play a role in clinical situations where endogenous NO production is critically important, such as neonatal pulmonary hypertension, increased pulmonary artery pressure following surgical repair of congenital heart defects or hepatovenocclusive disease following bone marrow transplantation ]

Product Specifications

Recombinant Human Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1354-1500aa, with N-terminal 6xHis-tagged tag, molecular weight 18.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell

Subcellular Location

Mitochondrion; Nucleus, nucleolus; Cell membrane (Peripheral membrane protein)

Disease Association

Carbamoyl phosphate synthetase 1 deficiency (CPS1D) : An autosomal recessive disorder of the urea cycle causing hyperammonemia. It can present as a devastating metabolic disease dominated by severe hyperammonemia in neonates or as a more insidious late-onset condition, generally manifesting as life-threatening hyperammonemic crises under catabolic situations. Clinical features include protein intolerance, intermittent ataxia, seizures, lethargy, developmental delay and intellectual disability. [The disease is caused by variants affecting the gene represented in this entry] | [CPS1 protein variants might influence the availability of precursors for nitric oxide (NO) synthesis and play a role in clinical situations where endogenous NO production is critically important, such as neonatal pulmonary hypertension, increased pulmonary artery pressure following surgical repair of congenital heart defects or hepatovenocclusive disease following bone marrow transplantation (PubMed:11407344)]

Tissue Specificity

Primarily in the liver and small intestine

Subunit

Can form homooligomers (monomers as predominant form and dimers)

Gene: CPS1  |  Organism: Homo sapiens  |  Synonyms: Carbamoyl-phosphate synthetase I
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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