Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 34.3 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) (Active)

Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) (Active) — Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Purity >95%.

SKU: BCACP-000261 Category:
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Product SKUBCACP-000261
Product DescriptionRecombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 35-320aa. [Accession | P31997].
Uniprot No.P31997
Gene NamesCEACAM8
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region35-320aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight34.3 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human BTLA at 2 μg/mL can bind Anti-BTLA recombinant antibody. The EC50 is 11.56-13.00 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCGM6

Function

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.

Biological Context

Subcellular Location: Cell membrane (Lipid-anchor, GPI-anchor); Cell surface
Tissue Specificity: Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow

Product Specifications

Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 35-320aa, with C-terminal 10xHis-tagged tag, molecular weight 34.3 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human BTLA at 2 μg/mL can bind Anti-BTLA recombinant antibody. The EC50 is 11.56-13.00 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:11590190, PubMed:2022629, PubMed:8776764). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:11590190, PubMed:2022629, PubMed:8776764). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764)

Subcellular Location

Cell membrane (Lipid-anchor, GPI-anchor); Cell surface

Tissue Specificity

Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow

Subunit

Monomer. Heterodimer with CEACAM6; heterodimerizes via its Ig-like V-type domain

Gene: CEACAM8  |  Organism: Homo sapiens  |  Synonyms: CD67 antigen; Carcinoembryonic antigen CGM6; Carcinoembryonic antigen-related cell adhesion molecule 8; Non-specific cross-reacting antigen NCA-95
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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